Let's look at easily confused words. (These have also come from blog readers.)
One of the most common is lose and loose. I don't know why this is a problem, because the meanings are obvious; I suppose it's the spelling. Here's a mnemonic device a friend suggested: He's as loose as a goose. By saying it aloud, he says he gets the sound and spelling correct.
Another help is to pronounce the word aloud. If it has an audible Z sound, then you write lose. If you use the hissing S sound, it's loose.
Orientate and orient. British writers seem to prefer orientate; in the US, we use orient. That's the only difference I see. On several websites, some have argued that orientate isn't a proper word (and they're wrong).
My opinion is that people who want to sound better educated than they are tend to use more ostentatious words such as orientate.